Ferroptosis　is　a　newly　defined　programmed　cell　death,　which　by　its　mechanism　differs　from　other　programmed　cell　death　processes　such　as　apoptosis,　necrosis,　and　autophagy.　It　has　a　unique　morphology　and　biological　properties　that　antioxidants　and　iron-chelating　agents　can　regulate.　Ferroptosis　has　the　characteristics　of　iron　ion　deposition　and　dependence　on　lipid　peroxidation.　It　can　affect　the　progression　of　many　cancers,　including　liver　cancer,　by　inducing　an　intracellular　iron-dependent　accumulation　of　reactive　oxygen　species,　providing　new　possibilities　for　cancer　treatment.　At　present,　great　progress　has　been　made　in　exploring　the　molecular　mechanism　of　ferroptosis.　In　this　review,　we　summarize　the　characteristics,　mechanisms,　and　regulatory　factors　of　ferroptosis　in　detail,　discuss　the　progress　of　ferroptosis　research　in　liver　cancer,　and　provide　directions　and　new　ideas　for　the　treatment　of　hepatocellular　carcinoma.