In　producing　electrolytic　manganese　and　manganese-based　lithium　batteries,　Manganous　sulfate　solution　serves　as　a　crucial　intermediate　material.　During　the　preparation　of　manganese　sulfate　solution　by　acid　leaching,　the　removal　of　impurities　such　as　zinc,　nickel,　and　cobalt　ions　by　sulfide　precipitation　is　essential　for　obtaining　high-quality　metallic　manganese　and　high-purity　manganese　sulfate.　The　results　show　that　when　the　temperature　is　45　°C,　the　pH　is　5.60,　the　ammonium　sulfide　dosage　is　40　%,　the　time　is　5　min,　and　the　rotation　speed　is　650　rpm,　the　sulfidation　rates　of　zinc,　nickel　and　cobalt　are　99.07　%,　89.30　%,　and　87.70　%　respectively.　At　this　time,　the　loss　rate　of　manganese　in　the　solution　after　sulfide　impurity　removal　is　11.45　%,　and　the　manganese-impurity　ratio　is　80.00.　Response　surface　methodology　analysis　revealed　that　temperature,　pH,　and　ammonium　sulfide　concentration　significantly　affected　the　manganese　loss　rate.　After　process　optimization,　at　a　temperature　of　32.70　°C,　a　pH　of　5.20,　and　an　ammonium　sulfide　concentration　of　32.73　%,　the　manganese　loss　rate　decreased　to　6.05　%,　while　the　removal　rates　of　Ni,　Co,　and　Zn　were　75.35　%,　60.80　%,　and　99.51　%,　respectively.　In　the　Manganous　sulfate　electrolyte　with　or　without　ammonium　sulfate,　the　sulfide　precipitation　processes　of　zinc,　nickel　and　cobalt　ion　are　all　first-order　reactions,　and　the　reaction　order　is　zinc　＞　nickel　＞　cobalt.　More　importantly,　the　density　functional　theory　(DFT)　calculation　results　also　confirmed　the　formation　sequence　of　zinc　sulfide　＞　nickel　sulfide　＞　cobaltous　sulfide,　which　supported　the　experimental　results　well.　This　study　will　lay　the　foundation　for　process　optimization　and　mechanism　elucidation　of　impurity　ions　in　ammonium　sulfate　electrolyte　precipitated　by　ammonium　sulfate.　©　2024　Elsevier　B.V.