Nitrogen　oxide　(NOx)　and　volatile　organic　compounds　(VOCs)　pose　a　severe　threat　to　human　health　and　eco-environment.　Synergistic　catalytic　degradation　has　sparked　significant　interest　in　multipollutant　control,　especially　for　industries　with　limited　space　for　technological　upgrades　to　satisfy　more　stringent　emission　regulations.　However,　it　is　still　in　the　early　stages　of　development　and　faces　many　issues　and　challenges,　such　as　highly　efficient　catalyst　design,　uncertain　reaction　mechanism　for　multipollutant　removal,　impact　of　other　components　in　complex　flue　gas　on　the　synergistic　catalytic　degradation,　and　environmental　risk　assessment　of　synergistic　catalytic　degradation　in　terms　of　byproduct.　This　review　summarizes　the　advantage　and　disadvantage　of　common　reported　catalysts　for　synergistic　catalytic　degradation,　discusses　the　factors　affecting　the　performance　and　the　optimization　technique　from　the　standpoint　of　acidity　and　redox　characteristics,　refines　the　synergistic　catalytic　degradation　mechanism　and　deactivation　process　due　to　the　presence　of　toxic　component,　and　highlights　the　category　and　formation　mechanism　of　the　potential　byproduct　during　the　synergistic　catalytic　degradation.　It　will　provide　a　reference　for　ongoing　in-depth　research　and　real-world　industrial　application　in　the　area　of　synergistic　catalytic　degradation　of　NOx　and　VOCs.　©　2024　Elsevier　B.V.