Economic　viability　and　durability　are　pivotal　challenges　limiting　the　commercial　application　of　proton　exchange　membrane　fuel　cells　(PEMFC).　The　development　of　low　Pt　usage　oxygen　reduction　reaction　catalysts　with　high　catalytic　activity　and　durability　is　imperative.　Carbon　support　corrosion,　as　well　as　Pt　particles　agglomeration　and　exfoliation　are　primary　causes　of　commercial　Pt/C　catalyst　degradation.　Here,　a　composite　materials　formed　by　TiO2　containing　oxygen　vacancy　(O-V)　and　carbon　nanotube　(CNT)　was　used　as　a　functional　support　to　successfully　load　Pt　nanoparticles　(NPs).　The　oxygen　vacancy　facilitated　interactions　between　TiO2(O-V)　and　Pt,　enhancing　the　anchoring　of　Pt　NPs　and　suppressing　particle　growth.　The　Pt/TiO2(O-V)-CNT　demonstrates　excellent　performance　with　mass　activity　of　788　mA/mg(Pt)　@0.85　V,　the　half-wave　potential　increased　34　mV　and　the　tafel　slope　decreased　by　11.89　mVdec(-1)　compared　to　commercial　Pt/C.　The　durability　of　Pt/TiO2(O-V)-CNT　nearly　3-fold　that　of　commercial　Pt/C　with　negligible　decay　of　half-wave　potential　(0.9　%)　and　mass　activity　(16　%).　Density　functional　theory　calculations　and　X-ray　photoelectron　spectroscopy　indicated　that　the　charge　transfer　from　TiO2(O-V)　to　Pt　facilitates　the　formation　of　strong　metal-support　interactions　(SMSI),　leading　to　a　downward　shift　in　the　d-band　center　of　Pt　and　a　reduction　in　the　binding　strength　to　*OOH,　thus　lowering　the　activation　energy　of　the　rate-determining　step　which　in　turn　promoting　the　activity　of　ORR.　This　study　provides　a　reliable　approach　for　designing　catalysts　with　high　activity　and　durability.