Lightweight　steel　structures　are　commonly　used　in　industrial　facilities　due　to　their　low　weight,　high　strength,　and　excellent　performance.　The　design　of　these　structures　for　cold　regions　not　only　has　to　consider　the　effects　of　earthquakes　but　also　the　negative　impact　of　snow　loads.　Industrial　structures　often　have　long　spans,　and　the　effects　of　uneven　snow　loads　cannot　be　underestimated.　However,　relatively　few　studies　have　focused　on　the　performance　of　lightweight　steel　structures　under　the　influence　of　combined　earthquake　and　non-uniform　snow　loads.　Therefore,　this　study　assessed　the　seismic　fragility　of　a　typical　single-span,　double-sloped　lightweight　steel　factory　under　combined　earthquake　and　non-uniform　snow　loads　using　incremental　dynamic　analysis.　Non-uniform　snow　loads,　as　compared　to　uniform　snow　loads,　substantially　increase　the　structural　displacement　responses,　thereby　increasing　the　structural　failure　risk.　The　improved　structural　design　developed　in　this　study　effectively　decreases　the　impact　of　adverse　loading　scenarios　and　enhances　the　multi-hazard　resilience　of　the　structure.　Accordingly,　these　results　can　serve　as　an　important　theoretical　guide　for　enhancing　the　safety　of　lightweight　steel　structures　subjected　to　multiple　hazards　in　cold　regions.