Hydrogen　peroxide　(H2O2)　is　a　versatile　and　zero-emission　material　that　is　widely　used　in　the　industrial,　domestic,　and　healthcare　sectors.　It　is　clear　that　it　plays　a　critical　role　in　advancing　environmental　sustainability,　acting　as　a　green　energy　source,　and　protecting　human　health.　Conventional　production　techniques　focused　on　anthraquinone　oxidation,　however,　electrocatalytic　synthesis　has　arisen　as　a　means　of　utilizing　renewable　energy　sources　in　conjunction　with　available　resources　like　oxygen　and　water.　These　strides　represent　a　substantial　change　toward　more　environmentally　and　energy-friendly　H2O2　manufacturing　techniques　that　are　in　line　with　current　environmental　and　energy　goals.　This　work　reviews　recent　advances　in　two-electron　water　oxidation　reaction　(2e-WOR)　electrocatalysts,　including　design　principles　and　reaction　mechanisms,　examines　catalyst　design　alternatives　and　experimental　characterization　techniques,　proposes　standardized　assessment　criteria,　investigates　the　impact　of　the　interfacial　milieu　on　the　reaction,　and　discusses　the　value　of　in　situ　characterization　and　molecular　dynamics　simulations　as　a　supplement　to　traditional　experimental　techniques　and　theoretical　simulations,　as　shown　in　Figure　1.　The　review　also　emphasizes　the　importance　of　device　design,　interface,　and　surface　engineering　in　improving　the　production　of　H2O2.　Through　adjustments　to　the　chemical　microenvironment,　catalysts　can　demonstrate　improved　performance,　opening　the　door　for　commercial　applications　that　are　scalable　through　tandem　cell　development.