Recently,　owing　to　the　prevalence　of　epidemic　and　pandemic　viral　diseases,　the　widespread　use　of　antiviral　drugs　(ATVs)　such　as　chloroquine　phosphate　(CQ)　and　lamivudine　(3TC)　has　raised　environmental　concerns　regarding　their　presence　in　wastewater.　In　this　study,　we　explore　our　previously　developed　Bi2O3-doped　TiO2　composites　supported　by　powdered　activated　carbon　(Bi2O3-TiO2/PAC;　BT/C)　catalysts　for　degrading　CQ　and　3TC　as　a　green　and　efficient　approach.　Under　suitable　conditions　(C0[ATV]　=　10　mg/L,　pH　=　7,　and　catalyst　dose　=　250　mg/L),　the　degradation　rates　of　CQ　and　3TC　reached　95.1%　and　57.1%　after　radiation　for　30　and　120　min,　respectively.　In　situ　irradiation　X-ray　photoelectron　spectroscopy　results　and　density　functional　theory　simulations　confirmed　that　BT/C　enhanced　interfacial　electron　transfer　from　TiO(2　)to　Bi2O3　and　suppressed　carrier　recombination.　Quenching　experiments　and　electron　paramagnetic　resonance　results　confirmed　O-2　-　generation,　leading　to　subsequent　OH　and　O-1(2)　production.　In　addition,　degradation　pathways　for　CQ　and　3TC　were　proposed.　Toxicity　assessments　indicated　reduced　overall　toxicity　during　photocatalysis.　BT/C　catalysts　proved　effective　across　diverse　water　qualities　and　maintained　stable　performance　through　repeated　use.　This　study　offers　new　insights　into　photocatalytic　ATV-removal　mechanisms　and　opens　avenues　for　innovative　hybrid　treatment　technologies.