The　Pt/CeO2　catalyst　has　attracted　significant　attention　due　to　its　exceptional　performance　in　NO　oxidation.　This　study　comprehensively　examines　the　effects　of　calcination　temperature　and　H-2　pretreatment　on　the　structure　and　activity　of　the　Pt/CeO2　catalyst.　Experimental　findings　indicate　that　the　calcination　temperature　significantly　affects　the　catalyst＇s　redox　performance,　thereby　modulating　its　efficacy　in　NO　oxidation　reactions.　H-2　pretreatment　facilitates　the　creation　of　oxygen　vacancies　on　the　catalyst,　assisted　by　the　reduction　in　PtOx　to　Pt,　enhancing　the　formation　of　activated　oxygen　and　thereby　improving　NO　oxidation.　This　study　offers　valuable　insights　into　the　design　and　optimization　of　Pt/CeO2　catalysts　for　environmental　applications,　particularly　in　the　development　of　exhaust　gas　after-treatment　technologies.