Air　pollution　adversely　affects　people＇s　health.　Under　the　current　background　of　compound　air　pollution　in　China,　the　emission　reduction　potential　of　air　pollution　control　has　significantly　decreased,　and　there　are　few　studies　on　multi-pollutant　emission　reduction　and　synergistic　effects.　PM2.5,　O3,　and　NO2　have　caused　the　enormous　disease　burden　and　health　risks.　This　study　evaluated　the　single　and　combined　health　effects　of　pollutants　in　the　Beijing-Tianjin-Hebei　region,　and　discussed　the　differences　in　susceptibility　among　disease　populations.　Identified　the　interactions　of　multiple　pollutants　and　evaluated　current　environmental　policies.　This　study　provided　evidence　of　the　interactive　effect　of　combined　PM2.5,　O3,　and　NO2　exposure　on　the　health　risks　of　different　disease　populations.　Among　them,　the　interaction　between　PM2.5　and　O3　posed　the　most　significant　health　risks　(Odds　Ratio　of　3.026)　and　had　the　greatest　impact　on　the　health　of　people　with　cardiovascular　diseases　(Odds　Ratio　of　3.136).　The　excess　deaths　affected　by　combined　exposure　exceeded　40　%　of　the　total　excess　deaths.　The　assessment　of　environmental　policies　indicated　that　compliance　with　the　AQG　2021　guideline　values　would　reduce　ambient　air　pollution-related　deaths　in　the　Beijing-Tianjin-Hebei　region　alone　by　about　30,000　per　year.　Our　national　standards　were　still　far　from　the　benchmarks　given　by　the　World　Health　Organization,　especially　for　NO2.　In　the　future,　attentions　should　also　be　paid　to　the　control　of　NO2　and　other　reaction　precursors　while　coordinating　the　control　of　PM2.5　and　O3.　©　2024　Elsevier　B.V.