The　advanced　oxidation　process　based　on　peroxymonosulfate　(PMS)　has　obvious　advantages　in　treating　antibiotic　wastewater,　but　finding　a　green,　economical　and　feasible　catalyst　still　be　a　key　for　its　large-scale　application.　In　this　research,　a　rectorite-based　metal　material　(FeCo2O4@C-REC)　was　synthesized　by　the　sol-gel　method,　and　its　catalytic　performance　and　mechanism　were　estimated　by　levofloxacin　(LVX,　a　typical　antibiotic　substance)　removal　through　activating　PMS.　A　more　than　80　%　LVX　removal　efficiency　can　achieve　in　10　min　under　the　conditions　of　pH　6.8,　catalyst　dosage　0.4　g/L　and　PMS　concentration　0.4　g/L.　Liquid　chromatography-mass　spectrometer　(LC-MS)　and　ECOSAR　analysis　showed　10　intermediates　appeared　in　LVX　degradation　process,　and　the　intermediates　pose　a　minimal　harm　to　the　ecosystem.　Quenching　experiments　and　Electron　Paramagnetic　Resonance　(EPR)　analysis　found　[rad]OH　and　SO4[rad]−　were　the　main　reactive　oxygen　species　(ROS)　for　LVX　degradation.　The　redox　between　a　large　number　of　hydroxyl　groups　Co　(iii)/Co　(ii)　and　Fe　(iii)/Fe　(ii)　on　REC　surface　played　an　important　role　for　activating　PMS　to　produce　ROS.　Different　water　matrices　experiments,　cycle　experiments,　and　metal　ion　leaching　tests　demonstrated　FeCo2O4@C-REC　had　a　good　applicability　and　stability　for　activating　PMS　to　degrade　LVX.　Our　study　may　provide　a　new　sight　for　catalyst　large-scale　application　to　remove　antibiotic　wastewater　though　PMS　activation.　©　2024