Sodium-ion　batteries　(SIBs)　and　potassium-ion　batteries　(PIBs)　have　enormous　potential　for　large-scale　energy　storage　due　to　their　cost-effectiveness,　safety,　and　environmental　compatibility.　Developing　high-capacity　and　highly　reliable　cathode　materials　is　key　to　advancing　the　commercialization　of　SIBs　and　PIBs.　Low-cost　Prussian　blue　analogs　(PBAs),　with　their　open　3D　framework　and　ease　of　synthesis,　are　preferred　cathode　materials　for　energy　storage　applications.　However,　the　unique　growth　mechanism　of　PBAs　introduces　numerous　Fe(CN)6　vacancies,　which　compromise　structural　integrity　and　result　in　capacity　decay　due　to　structural　collapse　during　long-term　electrochemical　cycling.　Additionally,　cracking　can　cause　the　dissolution　of　transition　metal　(TM)　ions,　undesirable　interfacial　reactions,　and　gas　generation,　which　shorten　the　battery＇s　lifespan　and　raise　safety　concerns.　In　this　review,　the　mechanisms　of　growth　and　vacancy　formation　in　PBAs　is　first　clarified,　providing　a　comprehensive　overview　of　current　strategies　for　vacancy　remediation　based　on　both　bottom-up　and　top-down　approaches.　It　is　then　elucidate　how　optimized　vacancy　remediation　mechanisms　can　enhance　lattice　and　interfacial　stability,　suppress　TM　dissolution　and　mitigate　gas　generation.　Finally,　it　is　discussed　future　research　directions　and　provide　perspectives　on　the　further　development　of　high-performance　cathode　materials　for　SIBs　and　PIBs.　©　2024　Wiley-VCH　GmbH.