To　systematically　explore　the　seismic　performance　of　shear　walls　and　frame-shear　wall　structures　under　multi-directional　seismic　actions,　three　shear　wall　specimens　and　one　frame-shear　wall　specimen　are　fabricated　and　the　quasi-static　loading　tests　are　carried　out.　The　shear　wall　specimens　are　loaded　in　oblique　direction,　in-plane　direction,　and　out-of-plane　direction,　while　the　frame-shear　wall　specimen　is　loaded　in　the　in-plane　direction.　The　macroscopic　damage　phenomena　of　the　specimens　are　analyzed　to　investigate　the　influence　of　the　typical　performance　indicators　such　as　crack　propagation,　hysteresis　curves,　skeleton　curves,　and　stiffness　degradation　curves.　Subsequently,　the　equation　for　calculating　comprehensive　damage　indices,　which　can　accurately　reveal　the　damage　evolution　process　and　final　damage　severity　of　shear　wall　components,　is　proposed.　Based　on　the　calibrated　experiments,　the　appropriate　finite　element　software　is　used　to　simulate　quasi-static　loading　from　multiple　angles　on　shear　wall　and　frame-shear　wall　specimens.　The　time-history　analysis　are　conducted　on　the　frame-shear　wall　structural　system　from　multiple　angles　to　comparatively　analyze　the　seismic　performance　and　failure　modes　of　the　two　types　of　structures　under　different　loading　angles.　The　results　indicate　that　the　bearing　capacity,　the　energy　dissipation　capacity　and　the　lateral　stiffness　of　shear　walls　and　frame-shear　wall　structures　decrease　as　the　loading　angle　increases.　Significant　changes　in　crack　development　and　failure　modes　are　observed　under　out-of-plane　loading　for　both　types　of　structures,　with　the　structural　damage　degree　increasing　with　larger　angles.　There　is　an　urgent　need　for　further　analysis　and　enhancement　of　the　seismic　performance　of　these　structures　under　multi-directional　loading　conditions.