The　major　challenges　encountered　in　developing　catalysts　for　volatile　organic　compound　(VOCs)　treatments　by　catalytic　oxidation　are　related　to　the　low-temperature　oxidation　performance　and　water　resistance.　To　address　these　issues,　we　herein　develop　an　in　situ　hard-templating　method　to　prepare　the　Pt　or　Pd/mesoporous　TiO2-CeO2　catalyst　and　apply　it　for　the　oxidation　of　toluene.　It　was　found　that　the　Pt/mesoporous　TiO2-CeO2　catalyst　exhibited　outstanding　catalytic　performance　and　stability　under　the　high　humidity　(15　vol%　H2O)　condition.　Various　characterization　results　revealed　that　the　Pt/meso-TiO2-CeO2　catalyst　exhibited　excellent　catalytic　activity:　the　temperatures　at　toluene　conversions　of　50　and　90　%　were　195　and　214　degrees　C　at　a　space　velocity　of　30,000　mL　g-　1　h-　1,　with　the　TOFPt　values　and　specific　reaction　rates　at　160　and　180　degrees　C　being　70.34　x　10-3　and　153.13　x　10-3　s-　1,　and　1.80　and　3.92　mmol　gPt-1　s-　1,　respectively.　Such　excellent　performance　of　Pt/meso-TiO2CeO2　was　related　to　its　high　surface　area,　abundant　oxygen　vacancies,　high　active　oxygen　species　concentration,　good　low-temperature　reducibility,　and　strong　interaction　between　Pt　or　Pd　and　meso-TiO2-CeO2.　The　mechanism　of　toluene　oxidation　might　take　place　via　the　following　route:　Toluene　is　first　oxidized　to　benzyl　alcohol　and　benzoquinone,　then　converted　to　benzaldehyde,　benzoic　acid,　maleic　anhydride,　and　these　intermediates　are　finally　oxidized　to　CO2　and　H2O.