This　study　delves　into　improving　the　photo-piezocatalytic　efficiency　of　molybdenum　disulfide　(MoS2),　a　two-dimensional　piezoelectric　material　recognized　for　its　high　catalytic　potential.　We　focus　on　optimizing　MoS2′s　catalytic　capabilities　through　the　incorporation　of　cobalt　(Co)　in　three　unique　forms:　surface　regulation　(Co-loaded　MoS2:　Co/MoS2),　interface　regulation　(CoS2/MoS2　heterostructures),　and　structural　regulation　(Co-doped　MoS2:　Co-MoS2).　These　modifications　are　instrumental　in　enhancing　the　material＇s　redox　activity,　resilience　to　piezoelectric　stress,　and　charge　carrier　efficiency,　critical　factors　for　catalytic　performance.　The　catalytic　properties　of　each　Co-modified　MoS2　variant　were　rigorously　evaluated　through　antibiotic　degradation　tests,　with　experiments　conducted　under　varying　environmental　conditions　to　simulate　real-world　applications.　Notably,　Co/MoS2　demonstrated　relatively　excellent　catalytic　activity,　achieving　nearly　complete　degradation　of　tetracycline　when　subjected　to　photo-piezoelectric　synergistic　conditions.　Supporting　this,　density　functional　theory　(DFT)　calculations　revealed　that　Co　loading　amplifies　the　piezoelectric　properties　of　MoS2　by　increasing　its　dipole　moment　under　tensile　strain,　further　enhancing　its　catalytic　effectiveness.　This　study　presents　an　innovative　strategy　for　elevating　the　catalytic　performance　of　2D　photo-piezoelectric　catalysts,　with　implications　for　their　future　use　in　environmental　remediation　and　sustainable　energy　solutions.　©　2025