In　this　paper,　the　nanostructured　reactive　multilayer　films　(RMFs)　are　used　as　the　intermediate　layer　to　assist　laser　welding　of　Ti6Al4V　alloy.　During　the　welding　process,　the　heat　of　the　laser　ignites　the　RMFs,　and　the　heat　released　by　the　RMFs　reaction　instantaneously　reaches　the　liquidus　temperature　in　the　center　of　the　joint.　This　new　joining　method　is　helpful　in　reducing　the　laser　energy　input,　minimizing　the　increasing　brittleness　and　reducing　strength　effect　of　heat　affected　zone　of　the　titanium　alloy　base　material,　and　increase　the　joint　strength　of　welds.　The　experiment　confirmed　that　the　joint　with　the　Ni/Al　RMFs　as　the　intermediate　layer　can　achieve　a　shear　strength　of　396　MPa　at　700　W　laser　power,　which　is　3　times　as　high　as　that　of　the　direct　laser　welded　joints　without　using　Ni/Al　RMFs　at　the　same　power.　Moreover,　the　Ni/Al　RMFs　as　an　intermediate　layer　can　reduce　the　laser　power　required　for　welding　by　10-20%　without　lowering　the　joint　strength.　(C)　2019　The　Authors.　Published　by　Elsevier　Ltd.