The　effect　of　the　additional　cyclic　hardening　caused　by　the　non-proportional　loading　is　an　important　factor　influencing　fatigue　damage　for　GH4169　superalloy　under　multiaxial　variable　amplitude　loading.　In　this　paper,　the　damage　curve　rule　is　modeled　using　the　fatigue　damage　model,　which　takes　into　account　not　only　the　effect　of　the　additional　cyclic　hardening　caused　by　the　non-proportional　loading,　but　also　the　elastic-plastic　stress　state　of　material　during　the　cyclic　loading　process.　The　model　allows　the　non-linear　effect　of　loading　model　and　amplitude　on　fatigue　damage　at　different　load　levels,　also　considers　the　effect　of　non-proportional　loading,　and　does　not　include　the　material　constants.　The　fatigue　test　data　for　GH4169　super　alloy　have　been　used　to　verify　the　model.　Results　show　a　good　agreement　for　predicting　fatigue　damage　under　complicated　multilevel　loading.