N-6-Methyladenosine　(m6A)　is　the　most　prevalent　internal　modification　that　occurs　in　the　mRNA　of　eukaryotes　and　plays　a　vital　role　in　the　post-transcriptional　regulation.　Recent　studies　highlighted　the　biological　significance　of　m6A　modification　in　the　nervous　system,　and　its　dysregulation　has　been　shown　to　be　related　to　degenerative　and　neurodevelopmental　diseases.　Parkinson＇s　disease　(PD)　is　a　common　age-related　neurological　disorder　with　its　pathogenesis　still　not　fully　elucidated.　Reports　have　shown　that　epigenetic　mechanisms　including　DNA　methylation　and　histone　acetylation,　which　alter　gene　expression,　are　associated　with　PD.　In　this　study,　we　found　that　global　m6A　modification　of　mRNAs　is　down-regulated　in　6-OHDA-induced　PC12　cells　and　the　striatum　of　PD　rat　brain.　To　further　explore　the　relationship　mechanism　of　PD,　we　decreased　m6A　in　dopaminergic　cells　by　overexpressing　between　m6A　mRNA　methylation　and　molecular　a　nucleic　acid　demethylase,　FTO,　or　by　m6A　inhibitor.　The　results　showed　that　m6A　reduction　could　induce　the　expression　of　N-methyl-D-aspartate　(NMDA)　receptor　1,　and　elevate　oxidative　stress　and　Ca2+　influx,　resulting　in　dopaminergic　neuron　apoptosis.　Collectively,　m6A　modification　may　play　a　vital　role　in　the　death　of　dopaminergic　neuron,　which　provides　a　novel　view　of　mRNA　methylation　to　understand　the　epigenetic　regulation　of　Parkinson＇s　disease.