The　last　decade　has　seen　an　increase　in　neuroimaging　studies　examining　brain　connectivity.　The　current　study　examined　differences　of　structural　Connectome　for　57　normal　aging　subjects.　3T　MRI　acquisitions　included　high　resolution　3D　T1,　EPI　sequences　for　Diffusion　Tensor　Imaging　(DTI).　The　main　processing　procedure　included　three　main　steps:　(1)　preprocessing;　(2)　brain　parcellation　and　structural　connection　matrix　construction;　and　(3)　topological　properties　extraction.　Our　findings　suggest　that　the　topology　of　the　local　network　architecture　in　frontal　lobe　and　temporal　lobe　may　be　more　vulnerable　to　aging　effects　than　other　parts　of　brain.　©　2015　Taylor　&　Francis　Group,　London.