Introduction:　Cardiovascular　disease　is　closely　linked　to　pulse　waveform,　so　a　simple　and　real-time　portable　pulse　waveform　detecting　device　is　necessary　for　user.　Methods:　To　collect　PPG　signals,　a　reflective　PPG　sensor　was　placed　on　the　mouse　where　the　thumb　touched　during　mouse　using.　Pulse　signals,　after　filtered,　amplified　and　A　/　D　converted,　was　transformed　into　SCM　and　computed　heart　rate.　Then　data　will　be　transferred　into　computer　to　display　by　USB　connector.　Results:　After　the　actual　test　of　the　mouse,　the　mouse　used　well　and　the　sensor　can　be　measured　and　outputted　the　PPG　signals　well.　Discussion:　The　healthy　mouse　monitoring　PPG　and　heart　rate　can　affect　the　user　inadvertently　to　detect　and　record　the　pulse　and　heart　rate　when　using　the　mouse.　©　2013　Springer-Verlag.