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Author:

Zhang, Yuan (Zhang, Yuan.) | Ge, Liang (Ge, Liang.) | Du, Nan (Du, Nan.) | Fan, Guoqiang (Fan, Guoqiang.) | Jia, Kebin (Jia, Kebin.) (Scholars:贾克斌) | Zhang, Aidong (Zhang, Aidong.)

Indexed by:

EI Scopus

Abstract:

Many works have been done to identify functional modules in Protein-Protein Interaction (PPI) networks but the results are far from satisfaction. One main reason is that the PPI data generated from high-throughput experiments is noisy and incomplete. Solving the problem goes beyond what a single data source can provide and thus requires the integration of multiple information sources. To address this problem, we hereby propose a graph-based cluster ensemble method which integrates gene ontology (GO) and gene expression data with PPI networks. Experimental results show that our method is superior to the baseline methods and demonstrate the benefits of integrating multiple biological information sources and diverse clustering methods.

Keyword:

Bioinformatics Proteins Gene expression Algorithms Graphic methods

Author Community:

  • [ 1 ] [Zhang, Yuan]Beijing University of Technology, Beijing, 100124, China
  • [ 2 ] [Ge, Liang]State University of New York at Buffalo, Buffalo, 14260, United States
  • [ 3 ] [Du, Nan]State University of New York at Buffalo, Buffalo, 14260, United States
  • [ 4 ] [Fan, Guoqiang]Beijing University of Technology, Beijing, 100124, China
  • [ 5 ] [Jia, Kebin]Beijing University of Technology, Beijing, 100124, China
  • [ 6 ] [Zhang, Aidong]State University of New York at Buffalo, Buffalo, 14260, United States

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Source :

Year: 2012

Page: 567-569

Language: English

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 6

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