Driving　Fatigue　is　one　of　the　main　reasons　of　resulting　in　heavy　traffic　accident　and　is　an　important　part　of　accident　risk.　Road　Scene　is　one　of　the　main　exogenous　factors　contributing　to　fatigue.　Design　rationality　of　road　scene　plays　an　important　role　in　reducing　the　influence　of　driving　fatigue.　We　use　video　image　processing　technique　and　video　image　compressing　technique　to　research　the　relation　between　road　scene　and　driving　fatigue.　Consequently,　information　change　measurement　of　road　scene　over　time　involves　MPEG　compression　and　OpenCV　program.　The　presented　research　result　shows　highly　consistence　with　human　identified　solution　in　general　environment　and　will　lay　a　foundation　for　the　further　research　of　reveal　the　relation　between　road　scene　and　driving　fatigue.　©2009　IEEE.