Previous　studies　have　reported　the　enhanced　randomization　of　functional　brain　networks　in　patients　with　major　depressive　disorder　(MDD).　However,　little　is　known　about　the　changes　of　key　nodal　attributes　for　randomization,　the　resilience　of　network,　and　the　clinical　significance　of　the　alterations.　In　this　study,　we　collected　the　resting-state　functional　MRI　data　from　19　MDD　patients　and　19　healthy　control　(HC)　individuals.　Graph　theory　analysis　showed　that　decreases　were　found　in　the　small-worldness,　clustering　coefficient,　local　efficiency,　and　characteristic　path　length　(i.e.,　increase　of　global　efficiency)　in　the　network　of　MDD　group　compared　with　HC　group,　which　was　consistent　with　previous　findings　and　suggested　the　development　toward　randomization　in　the　brain　network　in　MDD.　In　addition,　the　greater　resilience　under　the　targeted　attacks　was　also　found　in　the　network　of　patients　with　MDD.　Furthermore,　the　abnormal　nodal　properties　were　found,　including　clustering　coefficients　and　nodal　efficiencies　in　the　left　orbital　superior　frontal　gyrus,　bilateral　insula,　left　amygdala,　right　supramarginal　gyrus,　left　putamen,　left　posterior　cingulate　cortex,　left　angular　gyrus.　Meanwhile,　the　correlation　analysis　showed　that　most　of　these　abnormal　areas　were　associated　with　the　clinical　status.　The　observed　increased　randomization　and　resilience　in　MDD　might　be　related　to　the　abnormal　hub　nodes　in　the　brain　networks,　which　were　attacked　by　the　disease　pathology.　Our　findings　provide　new　evidence　to　indicate　that　the　weakening　of　specialized　regions　and　the　enhancement　of　whole　brain　integrity　could　be　the　potential　endophenotype　of　the　depressive　pathology.　(C)　2017　Elsevier　Ltd.　All　rights　reserved.