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Author:

Zhang, Qi (Zhang, Qi.) | Gao, Bin (Gao, Bin.) | Chang, Yu (Chang, Yu.) (Scholars:常宇)

Indexed by:

Scopus SCIE

Abstract:

Background: Partial support, as a novel support mode, has been widely applied in clinical practice and widely studied. However, the precise mechanism of partial support of LVAD in the intra-ventricular flow pattern is unclear. Material/Methods: In this study, a patient-specific left ventricular geometric model was reconstructed based on CT data. The intra-ventricular flow pattern under 3 simulated conditions - "heart failure", "partial support", and "full support" - were simulated by using fluid-structure interaction (FSI). The blood flow pattern, wall shear stress (WSS), time-average wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT) were calculated to evaluate the hemodynamic effects. Results: The results demonstrate that the intra-ventricular flow pattern is significantly changed by the support level of BJUT-II VAD. The intra-ventricular vortex was enhanced under partial support and was eliminated under full support, and the high OSI and RRT regions changed from the septum wall to the cardiac apex. Conclusions: In brief, the support level of the BJUT-II VAD has significant effects on the intra-ventricular flow pattern. The partial support mode of BJUT-II VAD can enhance the intra-ventricular vortex, while the distribution of high OSI and RRT moved from the septum wall to the cardiac apex. Hence, the partial support mode of BJUT-II VAD can provide more benefit for intra-ventricular flow pattern.

Keyword:

Ventricular Remodeling Hemodynamics Heart-Assist Devices

Author Community:

  • [ 1 ] [Zhang, Qi]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China
  • [ 2 ] [Gao, Bin]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China
  • [ 3 ] [Chang, Yu]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China

Reprint Author's Address:

  • 常宇

    [Chang, Yu]Beijing Univ Technol, Sch Life Sci & BioEngn, Beijing, Peoples R China

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Source :

MEDICAL SCIENCE MONITOR

ISSN: 1643-3750

Year: 2017

Volume: 23

Page: 1043-1054

3 . 1 0 0

JCR@2022

ESI Discipline: CLINICAL MEDICINE;

ESI HC Threshold:190

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 5

SCOPUS Cited Count: 5

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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