Background:　Abnormal　Cu(II)　ions　levels　may　affect　many　biological　functions,　and　it　is　of　great　importance　to　detect　Cu(II)　ions　in　organisms.　Methods:　Herein,　we　report　a　near-infrared　(NIR)　fluorescent　probe　EtRh-N-NH2　for　the　detection　of　Cu(II).　In　the　probe　structure,　a　rhodamine　core　was　used,　and　a　hydrazine　group　was　employed　as　the　responsive　site.　Results　&　Conlusions:　EtRh-N-NH2　displayed　sensitive,　specific　and　fast　response　upon　Cu(II)　with　excellent　linear　relationship　between　the　concentration　and　fluorescence　emission　intensity　in　0-1　mu　M　range.　The　releasing　EtRh-COOH　exhibited　762　nm　of　emission　wavelength　with　a　75　nm　of　Stokes　shift.