Objective　To　investigate　the　effect　of　left　ventricular　assist　device　(LVAD)　and　aortic　graft　angle　on　hemodynamics　of　aortic　valve.　Methods　Three　models　of　aorta　and　aortic　valve　with　45°,　60°　and　90°　anastomosis　angles　between　LVAD　and　aorta　were　constructed,　and　an　in　vitro　pulsating　table　was　built　for　in　vitro　experiments.　Using　particle　image　velocimetry　(PIV)　system,　three　moments　in　the　cardiac　cycle　(T1　systolic　peak,　T2　rapid　closure,　T3　diastolic　peak),　were　selected　to　study　the　hemodynamic　state　of　aortic　valve.　Results　Velocity　vector,　vorticity　and　viscous　shear　stress　were　used　to　evaluate　the　effect　of　LVAD　anastomosis　angle　on　hemodynamics　of　aortic　valve.　During　the　period　of　rapid　valve　closure,　with　the　increase　of　graft　angle,　the　blood　flow　velocity　near　the　valve　wall,　the　average　vorticity　and　the　maximum　viscous　shear　stress　all　increased.　Conclusions　When　the　graft　angle　is　lower,　the　impact　velocity　of　blood　on　the　valve　is　smaller,　and　the　shear　force　on　the　valve　decreases,　so　that　the　valve　is　in　a　better　hemodynamic　environment.　This　study　provides　references　for　the　selection　of　anastomotic　angles　in　clinical　operations.　©　2023　Shanghai　Jiaotong　University　School　of　Medicine.　All　rights　reserved.