Nowadays,　global　warming　caused　by　the　increasing　levels　of　CO2　has　become　a　serious　environmental　problem.　Membrane　separation　technology　has　demonstrated　its　promising　potential　in　carbon　capture　due　to　its　easy　operation,　energy-efficientness　and　high　efficiency.　Interfacial　polymerization　process,　as　a　facile　and　well-established　technique　for　preparing　membranes　with　a　thin　selective　layer,　has　been　widely　used　for　fabricating　commercial　reverse　osmosis　and　nanofiltration　membranes　in　water　treatment　domain.　To　push　forward　such　an　interfacial　polymerization　process　in　the　research　of　CO2　separation　membranes,　herein　we　make　a　review　on　the　regulation　and　research　progress　of　the　interfacial　polymerization　membranes　for　CO2　separation.　First,　a　comprehensive　and　critical　review　of　the　progress　in　the　monomers,　nanoparticles　and　interfacial　polymerization　process　optimization　for　preparing　CO2　separation　membrane　is　presented.　In　addition,　the　potential　of　molecular　dynamics　simulation　and　machine　learning　in　accelerating　the　screen　and　design　of　interfacial　polymerization　membranes　for　CO2　separation　are　outlined.　Finally,　the　possible　challenges　and　development　prospects　of　CO2　separation　membranes　by　interfacial　polymerization　process　are　proposed.　It　is　believed　that　this　review　can　offer　valuable　insights　and　guidance　for　the　future　advancement　of　interfacial　polymerization　membranes　for　CO2　separation,　thereby　fostering　its　development.