Organic　solvent　nanofiltration　(OSN)　plays　important　roles　in　pharmaceutical　ingredients　purification　and　solvent　recovery.　However,　the　low　organic　solvent　permeance　under　cross-flow　operation　of　OSN　membrane　hampers　their　industrial　applications.　Herein,　we　report　the　construction　of　coffee-ring　structured　membrane　featuring　high　OSN　permeance.　A　water-insoluble　crystal　monomer　that　dissolved　in　EtOH/H2O　mixed　solvent　was　designed　to　react　with　trimesoyl　chloride　via　interfacial　polymerization.　Owing　to　the　diffusion　of　EtOH　to　n-hexane,　coffee-ring　nanostructure　on　the　support　membrane　appeared,　which　served　as　the　template　for　construction　of　coffee-ring　structured　membrane.　The　optimal　nanostructured　membrane　demonstrated　2.6-fold　enhancement　in　the　effective　surface　area　with　reduced　membrane　thickness.　Resultantly,　the　membrane　afforded　a　2.7-fold　enhancement　in　organic　solvent　permeance,　e.g.,　similar　to　13　LMH/bar　for　MeOH,　without　sacrificing　the　rejection　ability.　Moreover,　due　to　the　rigid　monomer　structure,　the　fabricated　membrane　shows　distinctive　running　stability　in　active　pharmaceutical　ingredients　purification　and　the　ability　for　concentration　of　medicines.