The　existing　evaluation　indexes　for　the　structural　progressive　collapse　resistance　are　related　to　the　specific　initial　local　failure　in　a　structural　system,　which　cannot　be　effectively　used　to　assess　the　progressive　collapse-resisting　performance　of　the　structure.　A　collapse　probability　index　and　a　resistance　reservation　index　were　proposed　based　on　the　analysis　of　structural　systems　under　all　typical　initial　local　failures　to　comprehensively　assess　the　progressive　collapse　resistance　of　overall　structural　systems.　A　simplified　method　to　evaluate　the　progressive　collapse　resistance　for　the　practical　engineering　was　also　suggested　to　feasibly　calculate　the　two　indexes.　The　numerical　examples　show　that　the　collapse　probability　index　decreases　and　the　resistance　reservation　index　increases　with　the　improvement　of　seismic　fortification　intensity　and　the　enhancement　of　slabs.　The　numerical　results　are　consistent　with　the　results　of　theoretical　analysis,　indicating　the　progressive　collapse　resistance　of　structures　can　be　quantitatively　assessed　by　the　two　proposed　indexes.　The　simplified　method　can　feasibly　measure　these　two　indexes　to　meet　the　requirement　of　engineering　design　and　optimization.