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Author:

Wu, Guanghui (Wu, Guanghui.) | Xu, Chuangye (Xu, Chuangye.) | Liu, Xiujian (Liu, Xiujian.) | Lin, Changyan (Lin, Changyan.) | Yang, Lin (Yang, Lin.) | Li, Haiyang (Li, Haiyang.) | Hou, Xiaotong (Hou, Xiaotong.) | Chen, Chen (Chen, Chen.) | Yang, Peng (Yang, Peng.)

Indexed by:

CPCI-S Scopus SCIE

Abstract:

A small implantable centrifugal left ventricular assist device, the CH-VAD (CH Biomedical Inc, JiangSu, China), featuring a magnetically levitated impeller is under development. The goal of this study is to validate hydrodynamic performance and hemocompatibility of the pump through in vitro studies. The hydraulic performance was quantified experimentally by using in vitro circulation loop system, and it turned out that the pump could deliver 5 L/min under a pressure of 100 mmHg at a rotational speed of approximate 3400 rpm. A series of in vitro tests were established according to ASTM F1841, the standard practice for the assessment of hemolysis in continuous-flow blood pumps. The results showed that the average normalized index of hemolysis (NIH) value of the VAD was 0.0007 +/- 0.0003 mg/dL. The magnetic levitation left ventricular assist device (LVAD) has good hemolytic performance and stable mechanical property. These acceptable performance results supported proceeding initial acute animal testing conditions.

Keyword:

magnetic levitation hemolysis test in vitro Left ventricular assist device (LVAD) normalized index of hemolysis (NIH)

Author Community:

  • [ 1 ] [Wu, Guanghui]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 2 ] [Xu, Chuangye]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 3 ] [Liu, Xiujian]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 4 ] [Lin, Changyan]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 5 ] [Yang, Lin]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China
  • [ 6 ] [Li, Haiyang]Capital Med Univ, Beijing Anzhen Hosp, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 7 ] [Hou, Xiaotong]Capital Med Univ, Beijing Anzhen Hosp, AnZhen Str 2, Beijing 100029, Peoples R China
  • [ 8 ] [Chen, Chen]CH Biomed Inc, Suzhou Ind Pk,East Bldg 2-6,Room 202, Nanjing 215125, Jiangsu, Peoples R China
  • [ 9 ] [Yang, Peng]CH Biomed Inc, Suzhou Ind Pk,East Bldg 2-6,Room 202, Nanjing 215125, Jiangsu, Peoples R China

Reprint Author's Address:

  • [Lin, Changyan]Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, AnZhen Str 2, Beijing 100029, Peoples R China;;[Yang, Lin]Beijing Univ Technol, Coll Life Sci & Bioengn, PingLeYuan Str 100, Beijing 100029, Peoples R China

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Source :

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

ISSN: 0219-5194

Year: 2017

Issue: 7

Volume: 17

0 . 8 0 0

JCR@2022

ESI Discipline: MOLECULAR BIOLOGY & GENETICS;

ESI HC Threshold:309

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 9

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