Background:　Veno-arterial　extracorporeal　membrane　oxygenation　(VAECMO),　including　central　ECMO　(cECMO)　and　peripheral　ECMO　(pECMO),　is　widely　used　in　cardiopulmonary　surgery.　The　outcomes　and　complications　of　both　types　of　ECMO　are　quite　different　from　each　other.　The　hemodynamic　differences　among　them　are　hypothesized　as　a　key　factor.　Hence,　a　numerical　study　was　conducted　to　test　this　hypothesis.　Material/Methods:　Ideal　cardiovascular　models　with　pECMO　and　cECMO　were　established.　The　aortic　pressure　and　flow　rate　were　chosen　as　boundary　conditions.　The　flow　pattern,　blood　flow　distributions,　flow　junction,　harmonic　index　(HI)　of　blood　flow,　wall　shear　stress　(WSS),　and　the　oscillatory　shear　index　(OSI)　were　calculated　to　evaluate　the　hemodynamic　states.　Results:　pECMO　could　achieve　better　upper　limb　and　brain　perfusion　(0.05458　vs.　0.05062　kg/s),　and　worse　lower　limb　perfusion　(0.03067　vs.　0.03401　kg/s).　There　exist　low　WSS　(＜0.4　pa)　regions　at　the　inner　and　posterior　wall　of　the　aorta,　and　high　WSS　(＞2　pa)　region　at　the　access　of　the　femoral　artery.　These　regions　also　have　relatively　high　OSI　value　(reaching　0.45).　In　contrast,　for　cECMO,　there　exist　high　WSS　at　the　posterior　wall　of　the　aortic　arch.　Conclusions:　The　hemodynamic　performances　of　various　types　of　ECMO　are　different　from　each　other,　which　maybe　the　key　reasons　for　the　differences　in　the　outcomes　and　complications.　Therefore,　for　pEMCO,　the　lower-extremity　ischemia　is　a　complication　that　must　be　considered.　The　type,　support　level,　and　duration　of　ECMO　should　also　be　carefully　regulated　according　to　the　patients＇　condition,　as　they　are　the　important　factors　related　to　vascular　complications.