A　numerical　simulation　is　performed　to　investigate　laminar　forced　convection　nanofluid　based　non-Newtonian　flow　in　a　horizontal　parallel　plate　with　discrete　regions　of　heating　and　cooling.　Water,　pseudo　plastic　and　dilatant　fluids　are　used　as　working　base　fluids.　Power-law　modelling　is　adopted　to　predict　the　effect　of　non-Newtonian　behaviour　on　the　thermal　performance　of　nanofluids　in　a　channel　with　heating　(cooling)　regions　placed　symmetrically　on　walls,　and　the　remaining　surfaces　are　considered　adiabatic.　The　velocity　and　temperature　fields,　heat　transfer　coefficient　ratio,　and　pressure　drop　are　investigated,　considering　the　influence　of　power-law　index　(n),　nanoparticle　volume　fraction　(phi),　Reynolds　number,　and　generalized　Prandtl　number.　It　is　observed　that　the　velocity　and　temperature　of　nanofluids　may　increase　or　decrease　considerably　by　changing　the　base　power-law　fluids.　The　results　reveal　that　nanofluids　based　on　dilatant　flow　are　more　sensitive　to　the　environmental　heat　flux　than　those　based　on　pseudo　plastic　fluid.　Furthermore,　the　pressure　drop　increases　as　the　power-law　index　rises.　The　findings　demonstrate　that　the　presence　of　non-Newtonian　effects　in　nanofluids　can　lead　to　improvement　and　optimization　in　the　thermal　performance　of　channels,　which　suggests　the　potential　of　nanofluid　based　power　law　flow　in　industrial　equipment　heating　and　cooling　applications.　(C)　2015　Elsevier　Ltd.　All　rights　reserved.