Alzheimer＇s　disease　(AD)　is　a　heterogeneous　disease　with　different　subtypes.　Studying　AD　subtypes　from　brain　structure,　neuropathology,　and　cognition　are　of　great　importance　for　AD　heterogeneity　research.　Starting　from　the　study　of　constructing　AD　subtypes　based　on　the　features　of　T1-weighted　structural　magnetic　resonance　imaging,　this　paper　introduces　the　major　connections　between　the　subtype　definition　and　analysis　strategies,　including　brain　region-based　subtype　definition,　and　their　demographic,　neuropathological,　and　neuropsychological　characteristics.　The　advantages　and　existing　problems　are　analyzed,　and　reasonable　improvement　schemes　are　prospected.　Overall,　this　review　offers　a　more　comprehensive　view　in　the　field　of　atrophy　subtype　in　AD,　along　with　their　advantages,　challenges,　and　future　prospects,　and　provide　a　basis　for　improving　individualized　AD　diagnosis.