Background:　Gray　matter　(GM)　density　and　cortical　thickness　(CT)　obtained　from　structural　magnetic　resonance　imaging　are　representative　GM　morphological　measures　that　have　been　commonly　used　in　Alzheimer＇s　disease　(AD)　subtype　research.　However,　how　the　two　measures　affect　the　definition　of　AD　subtypes　remains　unclear.　Methods:　A　total　of　180　AD　patients　from　the　ADNI　database　were　used　to　identify　AD　subgroups.　The　subtypes　were　identified　via　a　data-driven　strategy　based　on　the　density　features　and　CT　features,　respectively.　Then,　the　similarity　between　the　two　features　in　AD　subtype　definition　was　analyzed.　Results:　Four　distinct　subtypes　were　discovered　by　both　density　and　CT　features:　diffuse　atrophy　AD,　minimal　atrophy　AD　(MAD),　left　temporal　dominant　atrophy　AD　(LTAD),　and　occipital　sparing　AD.　The　matched　subtypes　exhibited　relatively　high　similarity　in　atrophy　patterns　and　neuropsychological　and　neuropathological　characteristics.　They　differed　only　in　MAD　and　LTAD　regarding　the　carrying　of　apolipoprotein　E　epsilon　2.　Conclusions:　The　results　verified　that　different　representative　morphological　GM　measurement　methods　could　produce　similar　AD　subtypes.　Meanwhile,　the　influences　of　apolipoprotein　E　genotype,　asymmetric　disease　progression,　and　their　interactions　should　be　considered　and　included　in　the　AD　subtype　definition.　This　study　provides　a　valuable　reference　for　selecting　features　in　future　studies　of　AD　subtypes.