Alzheimer＇s　disease　(AD)　is　a　disease　of　a　heterogeneous　nature,　which　can　be　disentangled　by　exploring　the　characteristics　of　each　AD　subtype　in　the　brain　structure,　neuropathology,　and　cognition.　In　this　study,　a　total　of　192　AD　and　228　cognitively　normal　(CN)　subjects　were　obtained　from　the　Alzheimer＇s　disease　Neuroimaging　Initiative　database.　Based　on　the　cortical　thickness　patterns,　the　mixture　of　experts　method　(MOE)　was　applied　to　the　implicit　model　spectrum　of　transforms　lined　with　each　AD　subtype,　then　their　neuropsychological　and　neuropathological　characteristics　were　analyzed.　Furthermore,　the　piecewise　linear　classifiers　composed　of　each　AD　subtype　and　CN　were　resolved,　and　each　subtype　was　comprehensively　explained.　The　following　four　distinct　AD　subtypes　were　discovered:　bilateral　parietal,　frontal,　and　temporal　atrophy　AD　subtype　(occipital　sparing　AD　subtype　(OSAD),　29.2%),　left　temporal　dominant　atrophy　AD　subtype　(LTAD,　22.4%),　minimal　atrophy　AD　subtype　(MAD,　16.1%),　and　diffuse　atrophy　AD　subtype　(DAD,　32.3%).　These　four　subtypes　display　their　own　characteristics　in　atrophy　pattern,　cognition,　and　neuropathology.　Compared　with　the　previous　studies,　our　study　found　that　some　AD　subjects　showed　obvious　asymmetrical　atrophy　in　left　lateral　temporal-parietal　cortex,　OSAD　presented　the　worst　cerebrospinal　fluid　levels,　and　MAD　had　the　highest　proportions　of　APOE　ε4　and　APOE　ε2.　The　subtype　characteristics　were　further　revealed　from　the　aspect　of　the　model,　making　it　easier　for　clinicians　to　understand.　The　results　offer　an　effective　support　for　individual　diagnosis　and　prognosis.