High-entropy　alloys　overcome　the　limitations　posed　by　traditional　alloys　due　to　features　such　as　high　strength,　toughness,　high　wear　resistance,　and　corrosion　resistance.　These　alloys　are　novel　metallic　materials　with　excellent　application　potential;　however,　typically　an　inverse　relationship　is　observed　between　the　strength　and　ductility　of　a　metal,　which　includes　high-entropy　alloys.　Therefore,　the　design　and　development　of　high　entropy　alloys　with　high　strength　and　high　ductility　have　become　a　limitation　in　current　research.　Recently,　heterostructure　design　has　achieved　great　success　in　strengthening　and　toughening　traditional　metallic　materials.　Heterostructured　and　high-entropy　alloys　has　garnered　much　attention　and　research　interest　to　realize　the　strength　and　toughness　of　high-entropy　alloys　with　high　strength　and　high　ductility.　This　study　reviews　the　existing　design　models　for　heterostructures　from　the　heterostructure　scale　perspective.　Furthermore,　the　effects　of　different　heterostructures　on　the　strengthening　and　toughening　mechanism　and　mechanical　properties　were　analyzed,　and　future　microstructural　designs　with　high　strength　and　toughness　were　anticipated.