To　consider　the　influence　of　epistemic　uncertainties　in　both　seismic　hazard　and　numerical　simulation　on　seismic　risk　of　subway　station　structures,　the　uncertainties　mentioned　above　are　uniformly　characterized　as　the　epistemic　uncertainty　of　seismic　demand　of　subway　station　structures　from　the　perspective　of　uncertainty　propagation　in　this　paper.　On　this　basis,　the　analytical　formulations　of　seismic　risk　considering　simultaneous　aleatory　and　epistemic　uncertainties　are　derived.　The　validity　of　the　derived　analytical　formulations　is　verified　by　the　Monte　Carlo　simulation　and　the　influences　of　epistemic　uncertainty　on　the　seismic　risk　of　subway　station　structure　are　further　discussed.