Polyoxometalates　(POMs),　as　a　class　of　multinuclear　metal　oxygen　clusters,　have　promising　biological　activities.　And　their　amino　acid　derivatives　will　lead　to　better　pharmacological　activity　by　the　diversity　in　structures　and　properties.　With　reference　to　the　anti-HIV-1　activities　of　PM-19　(K7PTi2W10O40)　and　its　pyridinium　derivatives,　a　series　of　novel　Keggin-type　POMs　with　amino　acid　as　organic　cations　(A7PTi2W10O40)　were　synthesized　by　hydrothermal　synthetic　method.　The　final　products　were　characterized　by　1H　NMR,　Elemental　analyzes　and　single　crystal　X-ray　diffraction.　All　the　synthesized　compounds　were　obtained　in　the　yields　of　44.3-61.7%　and　evaluated　the　cytotoxicity　and　anti-HIV-1　activity　in　vitro.　Compared　with　the　reference　compound　PM-19,　the　target　compounds　had　a　lower　toxicity　to　TZM-bl　cells　and　a　higher　inhibitory　activity　against　HIV-1.　Among　them,　compound　A3　showed　higher　anti-HIV-1　activity　with　IC50　of　0.11　nM　than　that　of　PM-19　with　4.68　nM.　This　study　demonstrated　that　combination　of　Keggin-type　POMs　and　amino　acids　can　be　a　new　strategy　to　enhance　the　anti-HIV-1　biological　activity　of　POMs.　All　results　will　be　expected　to　helpful　for　developing　more　potent　and　effective　HIV-1　inhibitors.