The　recently　emerged　Al-Mn-Mg-Sc-Zr　alloys　were　regarded　as　high-strength　Al　alloys　suitable　for　hightemperature　applications.　However,　the　influence　of　laser　powder　bed　fusion　(LPBF)　fabricated　anisotropic　microstructure　on　tensile　creep　performance　has　not　been　explored.　In　this　work,　we　reported　an　anisotropic　tensile　creep　behavior,　which　is　superior　in　the　vertical　specimens　than　the　horizontal　counterparts.　The　tensile　creep　anisotropy　was　attributed　to　the　bi-modal　microstructure　of　columnar　grains　within　melt　pool　and　equiaxed　grains　at　melt　pool　boundary,　the　＂fish-scale＂　melt　pool　morphology　and　the　resulted　tortuous　crack　path　in　the　vertical　orientation.