Tetrabromobisphenol　A　(TBBPA)　that　widely　exists　in　soil　and　poses　a　potential　threat　to　ecological　environment　urgently　needs　economically　efficient　remediation　techniques.　This　study　utilized　both　homogeneous　Fe2⁺　solution　and　heterogeneous　iron-based　nanomaterials　(chemically　synthesized　nano　zero-valence　iron　(nZVI)　and　green-synthesized　iron　nanoparticles　(G-Fe　NPs))　to　activate　persulfate　(PS)　and　assess　their　efficacy　in　degrading　TBBPA　in　soil.　The　results　demonstrate　the　superior　performance　of　heterogeneous　catalytic　systems　(WG-Fe　NPs/PS　(82.07%)　and　WnZVI/PS　(78.32%))　over　homogeneous　catalytic　system　(WFe2+/PS　(71.69%)),　In　addition,　G-Fe　NPs　and　nZVI　effectively　controlled　the　slow　release　of　Fe2+.　The　optimization　analysis　using　response　surface　methodology　(RSM)　reveal　the　remarkable　significance　of　the　experimental　model　based　on　the　box-behnken　design.　RSM　show　that　G-Fe　NPs/PS　exhibited　optimal　process　parameters　and　predicted　the　maximum　soil　TBBPA　degradation　efficiency　reaching　98.77%.　The　results　of　density　functional　theory　calculations　suggest　that　C–Br　are　the　primary　targets　for　electrophilic　substitution　reactions.　Based　on　the　f0　value　and　△G,　the　degradation　pathway　of　TBBPA　is　inferred　to　involve　a　sequential　debromination　process,　followed　by　the　cleavage　of　intermediate　carbon-carbon　bonds　and　subsequent　oxidation　reactions.　Hence,　G-Fe　NPs/PS　not　only　facilitate　waste　resource　utilization　but　also　hold　significant　application　potential.　©　2024