Aim　To　preliminarily　evaluate　the　effects　of　hypobaric　hypoxia　on　organism　damage　in　rats　with　post-traumatic　stress　disorder　(PTSD),　with　a　view　to　laying　a　foundation　for　drug　research　in　plateau　PTSD.　Methods　The　rats　were　randomly　divided　into　four　groups,　namely,　the　control　(Control)　group,　the　single-prolonged　stress　(SPS)　group,　the　hypobaric　hypoxia　(HH)　group　and　the　single-prolonged　stress　combined　with　hypobaric　hypoxia　(SPS　+　HH)　group.　The　PTSD　model　was　firstly　constructed　using　the　SPS　method　for　rats　in　the　SPS　and　SPS　+　HH　groups.　On　the　second　day,　rats　in　the　HH　group　and　SPS　+　HH　group　were　placed　in　a　low-pressure　hypoxia　chamber　at　a　simulated　altitude　of　6000　m　for　14　days.　General　condition,　behavior,　blood　tests,　and　histomorphology　were　examined　in　order　to　evaluate　the　damage　caused　by　low　pressure　hypoxia　in　PTSD　rats.　Results　The　body　mass　of　rats　in　the　SPS　+　HH　group　was　significantly　reduced;　the　feces　were　partly　hard　and　lumpy,　and　some　of　them　were　seen　to　have　high　viscosity.　Anxiety-like　and　depression-like　behaviors　were　observed　in　all　groups　except　in　the　control　group,　in　which　hypobaric　hypoxia　aggravated　the　behavioral　abnormalities　in　SPS　rats.　Rats　in　both　the　SPS　and　SPS　+　HH　groups　had　coagulation　dysfunction　and　abnormally　increased　blood　viscosity,　which　was　significantly　abnormal　in　the　SPS　+　HH　group;　erythrocytes,　hemoglobin,　and　erythrocyte　specific　volume　in　whole　blood　of　rats　in　the　SPS　+　HH　group　were　significantly　increased　compared　with　those　of　rats　in　the　SPS　group;　and　serum　TP,　LDH　and　GLU　levels　were　abnormal　in　rats　in　the　SPS　+　HH　group.　Dilated　and　congested　blood　vessels　were　seen　in　hippocampal　tissue,　congested　central　veins　were　seen　in　hepatic　tissue,　and　dilated　and　congested　liver　sinusoids　with　mild　granulomatous　degeneration　of　hepatocytes　were　seen　in　rats　of　the　SPS　+　HH　group.　Conclusion　Hypobaric　hypoxia　exacerbates　depression-like　and　anxiety-like　behaviors　in　PTSD　rats,　as　well　as　hematological　indices　and　his-tomorphometric　abnormalities　in　PTSD　rats.　©　2024　Publication　Centre　of　Anhui　Medical　University.　All　rights　reserved.