The　development　of　surface-enhanced　Raman　spectroscopy　(SERS)　as　an　ultrasensitive　fingerprint　analysis　technique　in　precision　medicine　requires　high-performance　SERS　substrates　with　controllable　nanostructure　(hot-spot)　distribution,　simple　fabrication,　superior　stability,　biocompatibility,　and　extraordinary　optical　responses.　Unfortunately,　fabrication　of　arbitrary　nanostructures　with　high　homogeneity　on　a　large　scale　for　SERS　is　still　challenging.　Herein,　we　report　an　ultrafast　laser　parallel　fabrication　protocol　for　Au/2D-transition-metal　dichalcogenide　hybrid　SERS　biosensors.　The　leveraged　photonic　nanojets　(PNJs)　are　generated　by　a　micron-sized　microsphere　monolayer　to　simultaneously　trigger　localized　phase　transition　in　2H-MoTe2,　achieving　a　1T′-MoTe2　nanopattern　array　with　a　density　of　1　million　per　mm2　by　a　single　laser　shot.　The　Au　nanoparticle　clusters　(AuNCs)　are　subsequently　grown　in　situ　from　the　1T′　regions,　creating　a　AuNCs　on　1T′/2H-MoTe2　(AuNCs@1T’/2H-MoTe2)　hybrid　SERS　substrate.　The　fabricated　feature　diameter　and　overlay　accuracy　of　the　patterned　AuNCs　are　210.1　±　3.4　and　9.2　±　1.7　nm,　respectively.　To　eliminate　background　noise,　we　designed　dimer-AuNCs@1T′/2H-MoTe2　(dAuNCs@1T′/2H-MoTe2),　achieving　a　detection　limit　of　10-13　M　with　an　enhancement　factor　of　4.9　×　108　for　the　methylene　blue　(MB)　analyte.　The　strong　localized　surface　plasmon　resonances　in　the　dAuNCs　as　well　as　efficient　charge　transfers　between　Au,　2H-MoTe2,　and　MB　contribute　to　the　majority　of　Raman　enhancement.　The　multiscale　dAuNCs@1T′/2H-MoTe2　array　provides　a　powerful　SERSome　(comprising　multiple　SERS　spectra)　platform　for　therapeutic　drug　monitoring,　by　which　we　successfully　identified　the　metabolic　behaviors　of　living　gastric　adenocarcinoma　cells　administered　with　two　drugs,　i.e.,　capecitabine,　oxaliplatin,　and　their　combination.　The　present　work　establishes　opportunities　for　creating　a　highly　ordered　nanopattern　array　for　ultrasensitive　SERSome　analysis　of　cell　metabolism　in　cancer　therapy.　©　2025　American　Chemical　Society.