The　meso-Co3O4　and　AgxAuyPd/meso-Co3O4　catalysts　were　prepared　using　the　KIT-6-templating　and　polyvinyl　alcohol-protected　NaBH4　reduction　methods,　respectively.　Various　techniques　were　used　to　characterize　physicochemical　properties　of　these　materials.　Catalytic　performance　of　the　samples　was　evaluated　for　methanol　combustion.　The　cubically　crystallized　Co3O4　support　displayed　a　three-dimensionally　ordered　mesoporous　structure.　The　supported　noble　metal　nanoparticles　(NPs)　possessed　a　surface　area　of　115-125　m(2)/g,　with　the　noble　NPs　(average　size　=　2.8-4.5　nm)　being　uniformly　dispersed　on　the　surface　of　meso-Co3O4.　Among　all　of　the　samples,　0.68　wt%　Ag0.75Au1.14Pd/meso-Co3O4　showed　the　highest　catalytic　activity　(T-50%　=　100　degrees　C　and　T-90%=　112　degrees　C　at　a　space　velocity　of　80000　mL　(g(-1)　h(-1)).　The　partial　deactivation　of　the　0.68　wt%　Ag0.75Au1.14Pd/meso-Co3O4　sample　due　to　water　vapor　or　carbon　dioxide　introduction　was　reversible.　It　is　concluded　that　the　good　catalytic　performance　of　0.68　wt%　Ag0.75Au1.14Pd/meso-Co3O4　was　associated　with　its　highly　dispersed　Ag0.75Au1.14Pd　alloy　NPs,　high　adsorbed　oxygen　species　concentration,　good　low-temperature　reducibility,　and　strong　interaction　between　Ag0.75Au1.14Pd　alloy　NPs　and　meso-Co3O4.　(C)　2019,　Dalian　Institute　of　Chemical　Physics,　Chinese　Academy　of　Sciences.　Published　by　Elsevier　B.V.　All　rights　reserved.