In　this　paper,　based　on　the　study　of　microbiological　hazards　real-time　automatic　alarm　system　for　space　applications　and　the　＇function　integrated　and　structure　miniature＇　of　the　microfluidic　real-time　PCR　detection　system,　we　have　developed　an　integrated　control　system　based　on　the　MCU　micro-processing　chip　for　the　control　of　constant　temperature　and　sampling　flow　velocity　of　microfluidic　PCR　system.　We　have　used　the　flexible　polyimide　film　instead　of　traditional　elements　such　as　copper　to　facilitate　the　flow　structure,　which　is　characterized　by　small　size,　light　weight　and　excellent　heat　transfer　efficiency,　applicable　to　the　space　environment.　For　the　PID　parameter　tuning,　by　simulating　the　Z-N　method　of　engineering　turning　based　on　the　MATLAB/Simulink,　a　simple　and　efficient　method　for　PID　parameters　turning　is　proposed　in　this　paper.　The　practical　application　shows　that　the　system　is　simple,　strong　applicability,　high　control　accuracy,　process　visualization,　fully　automation　control　and　adapt　to　the　requirements　of　the　space　environment.　It　satisfies　the　development　requirement　of　making　the　structural　miniature　and　the　function　integrated.　It　can　achieve　the　requirements　of　space　applications　by　correcting　and　calculating　the　detection　system　in　the　conditions　of　weightlessness.　©　(2015)　Trans　Tech　Publications.