Due　to　the　influence　of　centrifugal　force,　accurate　contact　stiffness　model　of　spindle-toolholder　joint　at　high　speeds　is　crucial　in　predicting　the　dynamic　behavior　and　chatter　vibration　of　spindle-toolholder　system.　In　this　paper,　a　macro-micro　scale　hybrid　model　is　presented　to　obtain　the　contact　stiffness　of　spindle-toolholder　joint　in　high　speeds.　The　hybrid　model　refers　to　the　finite　element　model　in　macro-scale　and　three-dimensional　fractal　model　in　micro-scale.　The　taper　contact　surface　of　spindle-toolholder　joint　is　assumed　flat　in　macro-scale　and　the　finite　element　method　is　used　to　obtain　the　pressure　distribution　at　different　speeds.　In　micro-scale,　the　topography　of　contact　surfaces　is　fractal　featured　and　determined　by　fractal　parameters.　Asperities　in　micro-scale　are　considered　as　elastic　and　plastic　deformation.　Then,　the　contact　ratio,　radial　and　torsional　contact　stiffness　of　spindle-toolholder　joint　can　be　calculated　by　integrating　the　micro　asperities.　Experiments　with　BT40　type　toolholder-spindle　assembly　are　conducted　to　verify　the　proposed　model　in　the　case　of　no　speed.　The　reasonable　intervals　of　spindle　speed　and　drawbar　force　can　be　obtained　based　on　the　presented　hybrid　model,　which　will　provide　theoretical　basis　for　the　application　and　optimization　of　the　spindle-toolholder　system.