A　lot　of　great　work　has　been　done　since　the　high　pressure　research　carried　out　on　synchrotron　radiation　facility　almost　40　years　ago.　The　history　of　high　pressure　single-crystal　diffraction　research　on　synchrotron　radiation　facility　has　also　been　more　than　20　years.　Recently,　with　the　development　of　synchrotron　X-ray　optical　techniques　and　high　pressure　technology,　especially　the　invention　and　improvement　of　large　opening　diamond　anvil　cell　(DAC),　high　pressure　single-crystal　X-ray　diffraction　(HPSXRD)　method　has　become　more　and　more　popular　in　high　pressure　studies.　The　HPSXRD　can　be　used　to　perform　structure　determination　and　refinement　to　obtain　the　information　about　lattice　parameter,　space　group,　atomic　coordinate　and　site　occupation.　Compared　with　powder　X-ray　diffraction,　the　HPSXRD　can　not　only　obtain　the　three-dimensional　diffraction　information　of　samples,　but　also　have　much　better　signal-to-noise　ratio.　Furthermore,　the　HPSXRD　data　can　be　used　to　study　the　electron　density　distribution　to　obtain　more　information　about　chemical　bonds　and　electron　distribution.　In　this　work,　we　introduce　the　HPSXRD　method　in　synchrotron　radiation　facilities,　including　the　knowledge　of　single-crystal　X-ray　diffraction　experimental　system,　DAC　for　HPSXRD,　sample　loading,　and　HPSXRD　data　processing.