A　novel　gas　diffusion　electrode　(GDE)　device　is　proposed　that　can　generate　hydrogen　peroxide　(H2O2)　efficiently　and　consume　less　energy　than　conventional　GDE　devices.　By　optimizing　the　mass　fraction　of　PTFE　(40%)　and　CB　loading　(0.4　mL　cm(-2)),　the　three-dimensional　nickel　foam　composite　electrode　(CB/PTFE/NF)　was　endowed　with　a　stable　solid-liquid-gas　three-phase　interface.　CB/PTFE/NF　was　used　as　the　cathode　to　efficiently　generate　H2O2　without　external　aeration　using　the　natural　air　flow　and　evolution　of　oxygen　at　the　mixed　metal　oxide　(MMO)　anode　as　the　oxygen　sources.　After　running　for　150　min　under　optimal　conditions,　the　H2O2　accumulation　was　398　mg　L-1,　the　yield　of　H2O2　reached　3.17　mg　h(-1)　cm(-2),　and　the　current　efficiency　and　energy　consumption　were　70%　and　9.7　kWh　kg(　1),　respectively.　The　electrode　had　a　good　stability,　and　the　H2O2　production　could　still　reach　385　mg　L-1　after　10　cycles.　Based　upon　the　proposed　GDE　device,　the　electro-Fenton　degradation　of　amoxicillin　(AMX)　was　investigated.　When　the　Fe2+　concentration　was　0.3　mM　and　the　initial　concentration　of　AMX　was　50　mg　L-1,　the　removal　efficiency　was　100%　after　30　min.　The　active　species　that　played　a　major　role　in　the　degradation　of　AMX　was　the　hydroxyl　radical.